Azithrocin 50ML

100410603300401

Azithrocin 50ML

185.00৳ 

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In Stock

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Description

Indications of Azithrocin 50 ml

Azithromycin is used to treat infections in the lower respiratory tract, such as bronchitis and pneumonia, as well as infections in the upper respiratory tract, such as sinusitis and pharyngitis/tonsillitis, otitis media, and skin and soft tissue infections. Azithromycin is used to treat non-gonococcal urethritis and cervicitis caused by Chlamydia trachomatis in both men and women with sexually transmitted infections.

Pharmacology of Azithrocin 50 ml

Azithromycin is acid-stable and can hence be taken orally with no requirement of security from gastric acids. It is promptly ingested; its assimilation is more prominent on a purge stomach. The time to top concentration in grown-ups is 2.1 to 3.2 hours for verbal measurement shapes. Due to the tall concentration in phagocytes, azithromycin is effectively transported to the location of contamination. Amid dynamic phagocytosis, huge concentrations of azithromycin are discharged. The concentration of azithromycin within the tissues can be over 50 times higher than in plasma. Typically due to particle catching and the tall lipid solubility.

Azithromycin’s half-life permits an expansive single measurement to be managed and however keeps up bacteriostatic levels within the contaminated tissue for a few days. Taking after a single 500 mg dosage, plasma concentrations of azithromycin declined in a polyphasic design with a cruel clear plasma clearance of 630 mL/min and a terminal end half-life of 68 hours. The drawn-out terminal half-life is thought to be due to broad take-up and ensuing discharge of medication from tissues. Biliary excretion of azithromycin, predominantly unaltered, could be a major course of disposal. Over the course of a week, around 6% of the managed measurements show up as unaltered medication in urine.

Dosage & Administration

Oral-

Adult:

  • 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days.
  • For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for the next 2 days may also be given.

Children:

  • 10 mg/kg body weight once daily for 3 days for children over 6 months
  • 200 mg (1 teaspoonful) for 3 days if body weight is 15-25 kg
  • 300 mg (1½ teaspoonfuls) for 3 days if body weight is 26-35 kg; 400 mg (2 teaspoonfuls) for 3 days if body weight is 36-45 kg.
  • In typhoid fever, 500 mg (2½ teaspoonfuls) once daily for 7-10 days is given.

Azithromycin Injection (For IV Infusion only): The recommended dose of Azithromycin for injection for the treatment of adult patients with community-acquired pneumonia due to the indicated organisms is:

  • 500 mg as a single daily dose by the intravenous route for at least two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 500 mg, administered as two 250-mg tablets to complete a 7 to 10-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with clinical response.
  • The recommended dose of Azithromycin for the treatment of adult patients with pelvic inflammatory disease due to the indicated organisms is 500 mg as a single daily dose by the intravenous route for one or two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 250 mg to complete a 7-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with clinical response. If anaerobic microorganisms are suspected of contributing to the infection, an antimicrobial agent with anaerobic activity should be administered in combination with Azithromycin.
  • The safety and effectiveness of azithromycin for injection in children or adolescents under 16 years have not been established.

Interaction of Azithrocin 50 ml

In the presence of food or an antacid, azithromycin absorption is reduced. Because of the risk of ergotism from Azithromycin’s interaction with the cytochrome P-450 system, it should be avoided in patients receiving ergot alkaloids. Because macrolides raise digoxin and cyclosporin plasma concentrations, caution should be used while taking them together. Azithromycin has not been found to interact with Warfarin, Theophylline, Carbamazepine, Methylprednisolone, or Cimetidine.

Contraindications

Patients who are hypersensitive to azithromycin or any other macrolide antibiotic should avoid taking it. Ergot derivatives and azithromycin should not be taken together. Patients with hepatic disorders should avoid azithromycin.

Side Effects of Azithrocin 50 ml

Azithromycin is a well-tolerated antibiotic with few adverse effects. Nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhea, headache, dizziness, and skin rashes are among the side effects, which are reversible as the medication is stopped.

Pregnancy & Lactation

Azithromycin falls into the B pregnancy category. Azithromycin has been shown in animal reproductive tests to cause no harm to the fetus. In pregnant women, there are no sufficient and well-controlled trials. Because animal reproduction studies do not always reflect human response, Azithromycin should only be administered during pregnancy if there are no other options. Azithromycin is not known to be secreted in breast milk. As a result, when Azithromycin is given to a nursing woman, vigilance should be observed.

Precautions & Warnings

Observation for signs of superinfection with non-susceptible organisms, especially fungus, is suggested with any antibiotic. In patients with renal impairment, there is no need to alter the dose.

Therapeutic Class

Macrolides

Storage Conditions

Keep away from light and heat in a dry location. Keep out of children’s reach.

Pharmaceutical Name of Azithrocin 50 ml

Beximco Pharmaceuticals Ltd

Generic of Azithrocin 50 ml

Azithromycin Dihydrate