Indications of Azimex 30 ml

Azithromycin is demonstrated for diseases (caused by helpless living beings) in lower respiratory tract diseases counting bronchitis and pneumonia, in upper respiratory tract contaminations counting sinusitis and pharyngitis/tonsillitis, in otitis media, and in the skin and delicate tissue diseases. In sexually transmitted infections in men and ladies, Azithromycin is shown within the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.

Pharmacology of Azimex 30 ml

Azithromycin is acid-stable and can subsequently be taken orally with no requirement of security from gastric acids. It is promptly ingested; its retention is more prominent on a purge stomach. Time to crest concentration in grown-ups is 2.1 to 3.2 hours for verbal measurement shapes. Due to the tall concentration in phagocytes, azithromycin is effectively transported to the location of the disease. Amid dynamic phagocytosis, expansive concentrations of azithromycin are discharged. The concentration of azithromycin within the tissues can be over 50 times higher than in plasma. This is often due to particle catching and tall lipid dissolvability.

Azithromycin’s half-life permits a huge single dosage to be managed and however keeps up bacteriostatic levels within the tainted tissue for a few days. Taking after a single 500 mg measurement, plasma concentrations of azithromycin declined in a polyphasic design with a cruel clear plasma clearance of 630 mL/min and a terminal end half-life of 68 hours. The delayed terminal half-life is thought to be due to broad take-up and ensuing discharge of medicating from tissues. Biliary excretion of azithromycin, predominantly unaltered, may be a major course of disposal. Over the course of a week, roughly 6% of the managed dosage shows up as unaltered sedate in pee.

Microbiology: Azithromycin acts by an official to the 50S ribosomal subunit of vulnerable microorganisms and, in this way, an interferometer with microbial protein amalgamation. Nucleic corrosive amalgamation isn’t influenced. Azithromycin has appeared to be dynamic against most confines of the taking after microorganisms, both in vitro and in clinical infections:

• Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumonia, Streptococcus pyogenes
• Aerobic and facultative gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae
• Other microorganisms: Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumonia, and Beta-lactamase generation ought to have no impact on azithromycin activity.
• Aerobic and facultative gram-positive microorganisms: Streptococci (Bunches C, F, G), Viridans gather streptococci
• Aerobic and facultative gram-negative microorganisms: Bordetella pertussis, Legionella pneu

Dosage & Administration

Oral-

Adult:

• 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days.
• For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for the next 2 days may also be given.

Children:

• 10 mg/kg body weight once daily for 3 days for children over 6 months
• 200 mg (1 teaspoonful) for 3 days if body weight is 15-25 kg
• 300 mg (1½ teaspoonfuls) for 3 days if body weight is 26-35 kg; 400 mg (2 teaspoonfuls) for 3 days if body weight is 36-45 kg.
• In typhoid fever, 500 mg (2½ teaspoonfuls) once daily for 7-10 days is given.

Azithromycin Injection (For IV Infusion only): The recommended dose of Azithromycin for injection for the treatment of adult patients with community-acquired pneumonia due to the indicated organisms is:

• 500 mg as a single daily dose by the intravenous route for at least two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 500 mg, administered as two 250-mg tablets to complete a 7 to 10-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with clinical response.
• The recommended dose of Azithromycin for the treatment of adult patients with pelvic inflammatory disease due to the indicated organisms is 500 mg as a single daily dose by the intravenous route for one or two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 250 mg to complete a 7-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with clinical response. If anaerobic microorganisms are suspected of contributing to the infection, an antimicrobial agent with anaerobic activity should be administered in combination with Azithromycin.
• The safety and effectiveness of azithromycin for injection in children or adolescents under 16 years have not been established.

Reconstitution procedure of suspension-

• Step 01: Shake the bottle well to loosen the powder.
• Step 02: Add boiled and cooled water up to the watermark on the bottle label.
• Step 03: Shake until powder is completely mixed with water.

Azithromycin should be taken at least 1 hour before or 2 hours after the meal.

Interaction of Azimex 30 ml

Azithromycin assimilation is diminished in the nearness of nourishment and stomach-settling agent. In patients accepting ergot alkaloids, Azithromycin ought to be dodged sense of the plausibility of ergotism coming about from the interaction of Azithromycin with the cytochrome P-450 framework. As macrolides increment the plasma concentration of digoxin and cyclosporin, caution ought to be worked out whereas co-administration. There has been no medicating intuition between Azithromycin and Warfarin, Theophylline, Carbamazepine, Methylprednisolone, or Cimetidine.

Contraindications

Patients who are hypersensitive to azithromycin or any other macrolide antibiotic should avoid taking it. Ergot derivatives and azithromycin should not be taken together. Patients with hepatic disorders should avoid azithromycin.

Side Effects of Azimex 30 ml

Azithromycin is a well-tolerated antibiotic with few adverse effects. Nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhea, headache, dizziness, and skin rashes are among the side effects, which are reversible as the medication is stopped.

Pregnancy & Lactation

The pregnancy Category of Azithromycin is B. Creature generation thinks about has illustrated that Azithromycin has no proof of hurt to the embryo. There are no satisfactory and well-controlled things about pregnant ladies. Since creature generation ponders are not continuously prescient of human reaction, Azithromycin ought to be utilized amid pregnancy as it were on the off chance that satisfactory choices are not accessible. It isn’t known whether Azithromycin is discharged in the breast drain. So, caution ought to be worked out when Azithromycin is managed by nursing ladies.

Precautions & Warnings

Observation for signs of superinfection with non-susceptible organisms, especially fungus, is suggested with any antibiotic. In patients with renal impairment, there is no need to alter the dose.

Therapeutic Class

Macrolides

Pharmaceutical Name of Azimex 30 ml

Drug International Ltd

Generic of Azimex 30 ml

Azithromycin Dihydrate