Generic

Glucosamine Sulfate + Diacerein

Indications

This pill is used to treat osteoarthritis.

Rheumatoid arthritis is a type of arthritis that affects the joints.

Injuries to the bones and joints

Pharmacology

Glucosamine: Glucosamine (2-amino-2-deoxy-alpha-D-glucose) could be a normal amino sugar, created by the body and found in certain nourishments. It is the foremost crucial building piece required for biosynthesis of glycosaminoglycans (Chokes) like Hyaluronic Corrosive, Keratan Sulfate and Chondroitin Sulfate. Chokes ties with protein and shape proteoglycans, the basic building piece of articular cartilage. When cartilage in a joint break down, Osteoarthritis creates. It too makes a difference to create tendons, ligament, nails and various other connective tissues. When we take misleadingly synthesized Glucosamine Sulfate supplement, it increments Glucosamine level within the body, hence encourages generation and repair of cartilage. Glucosamine too actuates chondrocytes within the cartilage which offer assistance deliver Chokes and proteoglycans.

In humans, approximately 90% of glucosamine sulfate delivered as an oral dose is absorbed through the digestive tract. The liver is the primary metabolizer, and it is eliminated primarily through urine.

Diacerein is a drug that is used to treat osteoarthritis. It also possesses anti-inflammatory, anti-pyretic, and analgesic properties. It reduces the production of InterLeukin-1 (IL-1), the major cytokine involved in cartilage breakdown, in vitro. It has been proven to have a disease-modifying impact in laboratory models of osteoarthritis and in human subjects with finger joint and knee osteoarthritis due to its particular mode of action.

Verbal bioavailability of Diacerein 56%. Concurrent admissions of nourishment delays the time to top concentration but related with a 25% increment in retention. In this manner, diacerein is best given with nourishment. Basically ties with protein egg whites. Diacerein is metabolized broadly (100%) in liver taking after verbal dosing. Urinary excretion of diacerein within the frame of its metabolites has extended between 35% and 60%.

Dosage & Administration

Use in adults: One tablet twice daily with food.

Use in children and adolescents: The safety and effectiveness of children and adolescents under the age of 18 years have not been established.

Interaction

Antacids containing aluminum and/or magnesium hydroxide can help to reduce Diacerein absorption. Antibiotics or laxatives can increase the risk of diarrhea.

Contraindications

Antacids containing aluminum and/or magnesium hydroxide can help to reduce Diacerein absorption. Antibiotics or laxatives can increase the risk of diarrhea.

Side Effects

Those who have a hypersensitivity to glucosamine or dicerein should avoid it.

Pregnancy & Lactation

This tablet is not recommended for use during pregnancy or nursing.

Precautions & Warnings

In the case of patients who are allergic to Glucosamine or Diacerein, caution should be exercised when administering this tablet.

Therapeutic Class

Stimulation of Cartilage formation.

Storage Conditions

Store in cool & dry place below 30ºC, protect from light & moisture. Keep out of reach of children.

Pharmaceutical Name

ACME Laboratories Ltd.