Description
Generic
Montelukast Sodium
Indications
Montelukast Sodium is demonstrated for:
- Prophylaxis and incessant treatment of asthma
- Acute avoidance of Exercise-Induced Bronchoconstriction (EIB)
- Relief of indications of Unfavorably susceptible Rhinitis (AR): Regular & Perpetual Unfavorably susceptible Rhinitis
Pharmacology
Montelukast could be a specific and orally dynamic leukotriene receptor enemy that represses the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are items of arachidonic corrosive digestion system and are discharged from different cells, counting pole cells and eosinophils. Cysteinyl leukotrienes and leukotriene receptor occupation have been connected with the pathophysiology of asthma & unfavorably susceptible rhinitis, counting aviation route edema, smooth muscle compression, and modified cellular action related with the provocative handle, which contribute to the signs and indications of asthma.
Dosage
Adults & adolescents (15 years & older)-
- Asthma & Allergic Rhinitis: 10 mg/day
- Exercise-Induced Bronchoconstriction: 10 mg/day
Pediatric patients (6 to 14 years)-
- Asthma & Allergic Rhinitis: 5 mg/day
- Exercise-Induced Bronchoconstriction: 5 mg/day
Pediatric patients (6 months to 5 years)-
- Asthma & Allergic Rhinitis: 4 mg/day
- Exercise-Induced Bronchoconstriction: Not recommended
Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. For prevention of Acute prevention of Exercise-Induced Bronchoconstriction, a single dose should be taken at least 2 hours before exercise.
Administration
Route of administration: Oral. Montelukast may be taken with or without food or as directed by the physician.
Interaction
With pharmaceutical: No measurements alteration is required when montelukast is co-administered with theophylline, prednisone, prednisolone, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative-hypnotics, non-steroidal anti-inflammatory specialists, benzodiazepines, decongestants, verbal contraceptives, and Cytochrome P450 (CYP) chemical inducers.
With nourishment and others: Bioavailability and other conditions were not essentially watched with nourishment & other conditions.
Contraindications
Montelukast is contraindicated in patients who are easily affected to any component of this item.
Side Effects
Common: Loose bowels, fever, gastrointestinal inconvenience, migraine, sickness, heaving, skin responses, upper respiratory tract infection.
Uncommon: Akathisia, uneasiness, arthralgia, asthenia, anomalous behavior, discouragement, discombobulation, tiredness, dry mouth, drain, peevishness, disquietude, muscle complaints, oedema, seizure, irregular sensation, rest disorders.
Rare: Angioedema, concentration disabled, confusion, eosinophilic granulomatosis with polyangiitis, erythema nodosum, visualization, hepatic clutters, memory misfortune, palpitations, pneumonic eosinophilia, self-destructive inclinations, tremor.
Pregnancy & Lactation
There are no satisfactory and well-controlled thinks about in pregnant ladies. Montelukast ought to be utilized amid pregnancy as it were on the off chance that clearly required. Montelukast is excreted in breast drain. So caution ought to be worked out when Montelukast is given to a nursing mother.
Precautions & Warnings
Montelukast isn’t indicated for utilize within the inversion of bronchospasm in intense asthma assaults, counting status asthmatic. Neuropsychiatric occasions counting disturbance, antagonistic vibe, anxiousness, discouragement, confusion, unsettling influence in consideration, dream variations from the norm, visualizations, a sleeping disorder, crabbiness, memory disability, eagerness, somnambulism, self-destructive considering and behavior (counting suicide) and tremor.
Therapeutic Class
Leukotriene receptor antagonists
Storage Conditions
Store in cool & dry put underneath 30°C, ensure from light & dampness. Keep out of reach of children.
Pharmaceutical Name
NAVANA PHARMACEUTICALS LTD