Generic

Fexofenadine Hydrochloride

Indications

Fexofenadine Hydrochloride is used to treat the symptoms of seasonal allergic rhinitis in both adults and children. It’s also used to treat the cutaneous signs of chronic idiopathic urticaria that aren’t too severe.

Pharmacology

Fexofenadine Hydrochloride is an antihistamine that works by blocking peripheral H1 receptors. After oral administration, it is rapidly absorbed and reaches maximal plasma concentration in 2-3 hours. It doesn’t appear to be able to pass through the blood-brain barrier.

Dosage & Administration

Seasonal Allergic Rhinitis-

Adults and children 12 years and older:

• Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
• In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

• Tablet: 30 mg twice daily or 60 mg once daily
• In case of impaired renal function: 30 mg once daily

Children from 2 to 11 years

• Suspension: 30 mg or 5 ml twice daily
• In case of impaired renal function: 30 mg or 5 ml once daily

Chronic Idiopathic Urticaria-

Adults and children 12 years and older:

• Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
• In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

• Tablet: 30 mg twice daily or 60 mg once daily
• In case of impaired renal function: 30 mg once daily

Children from 6 months to less than 2 years:

• Suspension: 15 mg or 2.5 ml (1/2 tsp) twice daily
• In case of impaired renal function: 15 mg or 2.5 ml (1/2 tsp) once daily

Children from 2 to 11 years:

• Suspension: 30 mg or 5 ml (1 tsp) twice daily
• In case of impaired renal function: 30 mg or 5 ml (1 tsp) once daily

Interaction

When administered with erythromycin or ketoconazole, the plasma levels of Fexofenadine Hydrochloride increased. Fexofenadine Hydrochloride absorption is reduced by antacids that include aluminum and magnesium hydroxide.

Contraindications

Patients who have a known hypersensitivity to Fexofenadine Hydrochloride or any of its components should not use it.

Side Effects

Headache, tiredness, sleepiness, nausea, dry mouth, and gastrointestinal problems are all common adverse effects.

Pregnancy & Lactation

Fexofenadine Hydrochloride is classified as pregnancy category C by the US Food and Drug Administration. So, unless the potential advantages to the other outweigh the potential dangers to the fetus, Fexofenadine Hydrochloride should be avoided during pregnancy and breastfeeding.

Precautions & Warnings

Patients who are old or have impaired renal function should be treated with caution.

Therapeutic Class

Non-sedating antihistamines

Storage Conditions

Store away from light and heat in a cool, dry area. Children should be kept out of reach.

Pharmaceutical Name

ACME Laboratories Ltd.