Generic

Fluorometholone Acetate

Indications

• Acute and chronic non-infectious conjunctivitis, as well as allergic keratitis, are treated with fluorometholone acetate ophthalmic suspension.
• Inflammation in the anterior chamber of the eye that is not infectious (including anterior uveitis, episcleritis and scleritis).
• Irritative symptoms following strabismus, cataract, and glaucoma surgery.

Pharmacology

Fluorometholone is a corticosteroid that has a strong anti-inflammatory effect while having no effect on intraocular pressure. Fluorometholone has anti-inflammatory properties that are at least 40 times stronger than Hydrocortisone. Phospholipase A2 inhibitory proteins are considered to be introduced by corticosteroids. These proteins are thought to regulate the manufacture of powerful inflammatory mediators like prostaglandins and leukotrienes by preventing the release of their common precursor, arachidonic acid. Phospholipase A2 releases arachidonic acid from membrane phospholipids. Fluorometholone degrades more quickly in tissue than other corticosteroids, hence it has less of an effect on intraocular pressure. Fluorometholone’s immunosuppressive effect is less pronounced than Dexamethasone’s.

Dosage and Administration

1 drop instilled into the conjunctival sac 2-4 times daily. During the initial 24 to 48 hours the dosage may be safely increased to 1 drop every hour. Care should be taken not to discontinue therapy prematurely. Shake well before use.

Interaction

Specific drug interaction studies have not been conducted with Fluorometholone ophthalmic suspension.

Contraindications

Acute superficial herpes simplex keratitis, fungal diseases of ocular structures, vaccinia, varicella and most other viral diseases of the cornea and conjunctiva, tuberculosis of the eye, hypersensitivity to the component of this mediaction.

Side Effects

Elevation of intraocular pressure with possible development of glaucoma, and frequent optic nerve damage, posterior subcapsular cataract formation, secondary ocular infection from pathogens liberated from ocular tissues, perforation of the globe delayed wound healing.

Pregnancy & Lactation

Safety of the use of topical steroids during pregnancy and lactation has not been established.

Precautions & Warnings

Before usage, give it a good shake. Intraocular pressure should be monitored if this product is used for more than 10 days.

Therapeutic Class

Ophthalmic Steroid preparations

Storage Conditions

Store in a cold, dry, and light-protected location. Keep out of children’s reach. After 4 weeks, throw away the container.

Pharmaceutical Name

Aristopharma Ltd.