Indications of Afix 200

When caused by sensitive strains of the identified bacteria, cefixime is approved for the treatment of the following infections:

• Urinary tract infections caused by Escherichia coli and Proteus mirabilis are not difficult.
• Haemophilus influenza, Moraxella catarrhalis, and Streptococcus pyogenes cause otitis media.
• Streptococcus pyogenes causes pharyngitis and tonsillitis.
• Streptococcus pneumoniae and Haemophilus influenzae induce acute bronchitis and acute exacerbations of chronic bronchitis.
• Neisseria gonorrhoeae causes uncomplicated gonorrhea (cervical/urethral).

Pharmaceutical Name of Afix 200

Aristopharma Ltd

Pharmacology

Cefixime is a semisynthetic third-generation cephalosporin antibiotic for oral use. At easily obtainable plasma concentrations, it is bactericidal against a wide range of gram-positive and gram-negative bacteria. By interfering with the synthesis of the bacterial cell wall, it kills bacteria. In the presence of the Beta-lactamase enzyme, it is extremely stable. As a result, many organisms resistant to penicillins and some cephalosporins may be sensitive to Cefixime due to the presence of beta-lactamases. It is absorbed about 40% to 50% of the time, whether it is given with or without food.

Dosage and Administration of Afix 200

The usual course of treatment is 7 days. This may be continued for up to 14 days depending on the severity of the infection.

Interaction of Afix 200

Carbamazepine: Concomitant use elevates the carbamazepine level. Warfarin and other anticoagulants: Concomitant use increases prothrombin time.

Contraindications

It is contraindicated in hypersensitivity to Cefixime or other cephalosporins.

Side Effects of Afix 200

In general, the medication is well tolerated. Diarrhea and stool alterations are the most common adverse effects, which are more typically associated with greater doses. Nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache, and dizziness are some of the other side effects. Rashes, pruritus, urticaria, drug fever, and arthralgia have all been described as allergic reactions. When the therapy was stopped, these effects usually decreased.

Pregnancy & Lactation

However, no suitable and well-controlled studies in pregnant women have been conducted. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Cefixime is not known to be excreted in human milk. When Cefixime is given to a breastfeeding mother, caution should be observed.

Precautions & Warnings

Individuals having a history of gastrointestinal disorders, particularly colitis, should be prescribed with caution. Patients with severe renal impairment, as well as those on continuous ambulatory peritoneal dialysis or hemodialysis, should be given the medicine with caution. Only in severe renal failure (creatinine clearance 20 ml/min) should the dosage be adjusted; in that case, a daily dose of 200 mg should not be exceeded.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Keep below 30ºC temperature, protected from light & moisture. Keep out of the reach of children.

Generic Name of Afix 200

Cefixime Trihydrate