Description
Indication of Adapel 10
Adapalene 0.1% cream and 0.3% gel are indicated for topical treatment of acne vulgaris.
Pharmacology
Adapalene acts on retinoid receptors that are commonly found in the skin of the face, back, and chest. Biochemical and pharmacological studies have demonstrated that Adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of that represent important features in the pathology of acne vulgaris. Adapalene binds with specific retinoic acid nuclear receptors that normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Absorption of Adapalene through human skin is low.
Dosage and administration of Adapel 10
Adapalene 0.1% cream: Fona® 0.1% cream should be applied to the affected areas of skin, once daily at night-time Fona® 0.3% gel: Fona® 0.3% gel should be applied to the entire face and any other affected areas of the skin, once daily in the evening A thin film of gel or cream should be applied to the skin areas where lesions present, using enough to cover the entire affected areas lightly
Interaction of Adapel 10
Contraindications
Adapalene should not be administered to individuals who are hypersensitive to Adapalene or any of its components.
Side effects of Adapel 10
Erythema, scaling, dryness, pruritus, burning sensation, skin irritation, stinging unburn, acne flares, etc. are commonly seen during the first month of therapy but usually lessen with continued use of the medication.
Pregnancy and lactation
Use Adapalene during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in breast milk. Exercise caution when administering Adapalene to a nursing mother.
Precaution and Warning
Adapalene should not be applied to cuts, abrasions, eczematous or sunburned skin.
Therapeutic Class
Topical retinoid and related preparations
Storage Conditions
Store below 25° C. and in a dry place. Do not freeze.
Generic Name of Adapel 10
Adapalene
Healthcare Pharmaceuticals Ltd
