Aclobet-N 15 GM


Aclobet-N 15 GM


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Indications of Aclobet-N 15 Cream

  • Short-term treatment of resistant eczemas is indicated with this formulation.
  • Neurodermatitis.
  • Secondary bacterial or fungal infection is present, suspected, or likely in psoriasis (excluding extensive plaque psoriasis).
  • Other inflammatory disorders haven’t responded well to less potent steroids.

Pharmacology of Aclobet-N 15 Cream

Clobetasol Propionate could be an exceptionally strong corticosteroid. It is endorsed to treat extremely fiery skin disarranges such as dermatitis and psoriasis that have not reacted to weaker corticosteroids. Neomycin Sulfate is an anti-microbial of the aminoglycoside sort and is utilized to treat diseases with microscopic organisms. Nystatin is an antifungal that murders parasites and yeasts by interferometer with their cell layers. The instrument of topical steroids like Clobetasol, in common, is hazyBe that as it may, Clobetasol Propionate is a profoundly dynamic corticosteroid with topical anti-inflammatory action. The major effect of Clobetasol Propionate on the skin may be a nonspecific anti-inflammatory reactionsomewhat due to vasoconstriction and diminished collagen union. Neomycin ties to the ribosomal 30s and 50s sub-units of vulnerable microscopic organisms and represses protein amalgamation. Neomycin also causes a misreading of the mRNA template’s genetic coding, resulting in the incorporation of erroneous amino acids into the developing polypeptide chain. Nystatin works by attaching to sterols in the fungus’ cell membrane, causing a shift in membrane permeability that allows intracellular components to flow out.

Dosage & Administration of Aclobet-N 15 Cream

Adults: Apply sparingly to the affected area once or twice daily until improvement occurs. In very resistant lesions, especially where there is hyperkeratosis, the anti-inflammatory effect of this preparation can be enhanced (if necessary) by occluding the treatment area with polythene. Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient’s condition being reviewed.

Elderly: This preparation is suitable for use in the elderly. Caution should be exercised in cases where a decrease in renal function exists and significant systemic absorption of Neomycin Sulphate may occur.

Children: This preparation is suitable for use in children (2 years and over) at the same dose as adults. A possibility of increased absorption exists in very young children, thus this cream/ointment is not recommended for use in neonates and infants (younger than 2 years).

Interaction of Aclobet-N 15 Cream

Following extensive systemic absorption, neomycin sulfate can exacerbate and extend the respiratory depressive effects of neuromuscular blocking drugs. Systemic exposure to Neomycin Sulphate is expected to be modest if administered according to the instructions, and medication interactions are unlikely to be substantial. There have been no reports of dangerous interactions with Clobetasol Propionate or Nystatin.


Rosacea, acne vulgaris, and perioral dermatitis, as well as primary cutaneous viral infection (e.g., Herpes simplex, chicken pox) and hypersensitivity to the preparation, are all contraindications.

Side Effects of Aclobet-N 15 Cream

As with other topical corticosteroids, delayed utilization of expansive sum or treatment of broad ranges can result in adequate systemic assimilation to deliver the highlights of hypercortisolism. The impact is more likely to happen in newborn children and children and in the event that occlusive dressings are utilizedDelayed and serious treatment with profoundly dynamic corticosteroid arrangements may cause neighborhood atrophic changes within the skin such as diminishing, striae, and dilatation of the shallow blood vessels, especially when occlusive dressings are utilized, or when skin folds are included. There are reports of pigmentation changes and hypertrichosis with topical steroids.

Pregnancy & Lactation

There is little evidence to support the use of topically administered Neomycin during pregnancy and breastfeeding. However, because neomycin in the maternal blood can pass the placenta and pose a potential risk of fetal harm, the preparation should not be used during pregnancy or lactation. Clobetasol Propionate’s safety in lactating women has not been demonstrated.

Precautions & Warnings

Adrenal suppression can occur even without blockage, therefore long-term continuous topical medication should be avoided wherever possible, especially in infants and children. If the preparation is applied to the eyelids, it must be carefully monitored to ensure that it does not enter the eye, as this could cause glaucoma. If the drug gets into the eye, the afflicted eye should be rinsed out completely with plenty of water.

Therapeutic Class

Clobetasol / Clobetasone & Combined Preparations

Storage Conditions


Store below 25°C temperature. Do not freeze. Keep out of reach of children.


Pharmaceutical Name of Aclobet-N 15 Cream

ACME Laboratories Ltd

Generic of Aclobet-N 15 Cream

Clobetasol Propionate + Neomycin Sulfate + Nystatin