Indications of Acetor 25mg Tablet

Hypertension: Acetor 25mg Tablet is used to treat Gentle to direct hypertension as an aide to thiazide treatment in patients who have not reacted successfully to thiazide treatment alone.

Severe hypertension: Where standard treatment has fizzled. Acetor 25mg Tablet is used to treat is viable alone or in combination with other antihypertensive operators, particularly thiazide sort of diuretics. The blood weight bringing down the impact of Cardopril and thiazides are around additive.

Congestive heart disappointment: It is additionally utilized as an aide to the treatment of extreme congestive heart disappointment.

Pharmacology of Acetor 25mg Tablet is used to treat

Captopril competitively represses the transformation of angiotensin I (ATI) to angiotensin II (ATII), in this way coming about in diminished ATII levels and aldosterone discharge. It moreover increments plasma renin action and bradykinin levels. Diminishment of ATII leads to diminished Na and water maintenance. This advances vasodilation and BP decrease.

Acetor 25mg Tablet Administration & Dosage

Diabetic nephropathy:

• Adult: Type 1 diabetics: 75-100 mg/day in divided doses.

Post-myocardial infarction:

• Adult: May be started 3-16 days after MI. Initially, 6.25 mg/day followed by 12.5 mg tid for 2 days, then 25 mg tid. Maintenance: 75-150 mg/day in 2 or 3 divided doses.

Hypertension:

• Adult: Initially, 12.5 mg bid, 1st dose preferably at bedtime to avoid precipitous fall in BP, gradually increased at 2-4-wk intervals according to the response. Maintenance: 25-50 mg bid. Max: 50 mg tid. Patients on diuretics: 6.25 mg bid.
• Child: Neonates and infants: 0.15 mg/kg. Max: 6 mg/kg in 2 or 3 divided doses according to response. Childn and adolescents: 0.3 mg/kg. Max: 6 mg/kg in 2 or 3 divided doses according to response.
• Elderly: Initially, 6.25 mg bid.

Heart failure:

• Adult: Initially, 6.25-12.5 mg bid or tid. Maintenance: 25 mg bid or tid. Max: 50 mg tid.
• Child: Initially, 0.25 mg/kg/day, increased up to 2.5 or 3.5 mg/kg/day in 3 divided doses.

Interaction of Acetor 25mg Tablet

Concurrent treatment with NSAIDs decreases hypotensive activity and increments the chance of nephrotoxicity. Added substance hyperkalaemic impact with K supplements, K-sparing diuretics, and other drugs (e.g. heparin). May increment hazard of leucopenia with procainamide, allopurinol, cytostatic or immunosuppressants. May increment chance of lithium harmfulness. Expanded chance of nitritoid responses with gold (Na aurothiomalate).

Contraindications

Angioedema related to past Pro inhibitor treatment, innate or idiopathic angioneurotic edema. Concomitant utilize with aliskiren in diabetic patients.

Acetor 25mg Tablet Side Effects

Neutropenia, weakness and thrombocytopenia; proteinuria, hoisted blood urea and creatinine, hoisted serum potassium and acidosis; hypotension, tachycardia; rashes ordinarily pruritic, may happen; Reversible and ordinarily self-restricting taste disability has been detailed. Stomatitis taking after aphthous ulcers has moreover been detailed.

Pregnancy & Lactation

Pregnancy Category D. There’s positive proof of human fetal chance, but the benefits from utilizing in pregnant ladies may be satisfactory in spite of the chance

Precautions & Warnings

Patients with bilateral renal artery stenosis, collagen vascular disease, aortic or mitral valve stenosis, volume, and/or Na depletion. Renal impairment. Lactation.

Therapeutic Class

Angiotensin-converting chemical (Pro) inhibitors

Storage Conditions of Acetor 25mg Tablet

Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.

Pharmaceutical Name of Acetor 25mg Tablet