Indications of Ace 60 ml

Fever, common cold, and influenza: Headache, toothache, earache, body ache, myalgia, dysmenorrhoea, neuralgia, and sprains. The pain of colic, back pain, post-operative pain, postpartum pain, chronic pain of cancer, inflammatory pain, post-vaccination pain, and fever of children. Rheumatism and osteoarthritic pain & stiffness of joints in fingers, hips, knees, wrists, elbows, feet, ankles, and top & bottom of the spine.

Pharmaceutical Name

Square Pharmaceuticals Ltd.

Pharmacology

Ace® is the formulation of Paracetamol, which is one of the safest and most widely used analgesics and antipyretics. Ace® produces analgesic action by elevation of the pain threshold and antipyresis through action on the hypothalamic heat-regulating center. Ace® exerts significantly milder side effects and is most unlikely to produce many of the serious side effects associated with aspirin and other NSAIDs. Ace® is rapidly and completely absorbed from the G.I.T. following oral administration and from the rectum after
rectal administration. The mean half-life of absorption from the upper small intestine is only 7 minutes. The drug is extensively metabolized in the liver and it has a plasma half-life of 1.5 to 3.0 hours. Ace® is not bound to plasma proteins to any extent.

Dosage & Administration of Ace 60 ml

Tablet:

• Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.
• Children (6-12 years): ½ to 1 tablet 3 to 4 times daily. For long-term treatment, it is wise not to exceed the dose beyond 2.6 gm/day.

Extended Release Tablet:

• Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours). The tablet must not be crushed.

Syrup/Suspension:

• Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.
• 3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.
• 1-5 years: 1 -2 teaspoonfuls 3 to 4 times daily.
• 6-12 years: 2-A teaspoonfuls 3 to 4 times daily.
• Adults: 4-8 teaspoonfuls 3 to 4 times daily.

Suppository:

• Children 3-12 months: 60-120 mg,4 times daily.
• Children 1-5 years: 125-250 mg 4 times daily.
• Children 6-12 years: 250-500 mg 4 times daily.
• Adults & children over 12 years: 0.5-1 gm 4 times daily.

Pediatric Drop:

• Children Upto 3 months: 0.5 ml (40 mg)
• 4 to 11 months: 1.0 ml (80 mg)
• 7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 doses daily for a maximum of 5 days.

Paracetamol tablet with actizorb technology: It dissolves up to five times faster than standard Paracetamol tablets. It is a fast-acting and safe analgesic with marked antipyretic properties. It is especially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics.

• Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.
• Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.

Interactions of Ace 60 ml

Patients taking barbiturates, tricyclic antidepressants, and alcohol may have a reduced ability to metabolize large doses of paracetamol. Alcohol can increase liver toxicity from acetaminophen overdose. Long-term use of oral contraceptives or steroidal contraceptives may induce liver enzymes and may prevent therapeutic levels of paracetamol from being achieved by increasing metabolism or first-pass clearance.

Contraindications

Known sensitivity to paracetamol.

Side Effects of Ace 60 ml

Side effects are significantly mild, though hematological reactions have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.

Pregnancy & Lactation

Paracetamol is safe in all stages of pregnancy and lactation.

Precautions & Warnings

Paracetamol should be used with caution in patients with impaired kidney or liver function. Patients taking other medications that affect the liver should use acetaminophen with caution.

Therapeutic Class

Non opioid analgesics

Storage Conditions

Ace® tablet, syrup, and suspension: Store at a cool and dry place, and protect from light and moisture. Ace® suppository: Store below 30˚ C.

Generic Name of Ace 60 ml

Paracetamol