A-Flox 250 MG


A-Flox 250 MG


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Flucloxacillin Sodium



Flucloxacillin is used to treat infections produced by Gram-positive bacteria, particularly infections caused by staphylococci that produce penicillinase. These are some of the signs:

  • Infections of the skin and soft tissues: boils, abscesses, carbuncles, and infected skin diseases (e.g. ulcer, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns, otitis media and externa, impetigo).
  • Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, and quinsy are all respiratory tract illnesses.
  • It is also used to treat other infections caused by Flucloxacillin-sensitive organisms, such as osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, and septicaemia.



Flucloxacillin is dynamic against Gram-positive life forms counting penicillinase creating strains. It has small movement against Gram-negative bacilli. Flucloxacillin acts by repressing the arrangement of cell divider of microbes. Flucloxacillin is isoxazolyl penicillin which combined the properties of resistance to hydrolysis by penicillinase, gastric corrosive solidness and movement against gram-positive microscopic organisms. Flucloxacillin could be a bactericidal anti-microbial that’s especially valuable against penicillinase-producing staphylococci. Flucloxacillin kills bacterial cellwall, in this way interferometer with peptidoglycan blend. Peptidoglycan could be a heteropolymeric structure that gives the cell divider with its mechanical steadiness. The ultimate organize of peptidoglycan union includes the completion of the cross-linking with the terminal glycine buildup of the pentaglycin bridge connecting to the fourth buildup of the pentapeptide (D-alanine).


Dosage & Administration

Oral administration:

  • Adult: 250 mg four times daily. Dosage may be doubled in severe infections. In osteomyelitis and endocarditis, up to 8 gm daily is used in 6-8 hourly divided doses.
  • Children (2-10 years): 1/2 of adult dose.
  • Children (Under 2 years): 1/4 of adult dose.

Parenteral administration:

Adult or Elderly:

  • Intramuscular Injection: 250 mg four times daily.
  • Intravenous Injection: 250 mg-1 g four times daily by slow injection over 3 to 4 minutes or by intravenous infusion.
  • All systemic doses may be doubled in severe infections: doses up to 8 g daily have been suggested for endocarditis or osteomyelitis.


  • 2-10 years: half of the adult dose.
  • Under 2 years: a quarter of the adult dose.



Concurrent Flucloxacillin use may result in an elevated Flucloxacillin level in the blood for an extended length of time.



In patients with penicillin hypersensitivity, flucloxacillin is not recommended.


Side Effects

Nausea, vomiting, diarrhoea, dyspepsia, and other minor gastrointestinal problems are some of the most prevalent gastrointestinal side effects. Urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice have all been documented in addition to these rashes.


Pregnancy & Lactation

Flucloxacillin is classified as a pregnancy category B by the US Food and Drug Administration. In pregnant women, there are no sufficient and well-controlled trials. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Human milk has been found to contain flucloxacillin. When Flucloxacillin is given to a nursing woman, vigilance should be observed.


Precautions & Warnings

Flucloxacillin should be used with caution in patients with evidence of hepatic dysfunction. Caution should also be exercised in the treatment of patients with an allergic diathesis.


Therapeutic Class

Penicillinase-resistant penicillins


Storage Conditions

Keep away from light and heat in a dry location. Keep out of children’s reach.


Pharmaceutical Name

ACME Laboratories Ltd.